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Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

lactide:glycolide (75:25), mol wt 66,000-107,000

Sinônimo(s):

LACTEL® B6007-1, PLGA

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About This Item

Fórmula linear:
[C3H4O2]x[C2H2O2]y
Número MDL:
MFCD00131930
Código UNSPSC:
12162002
ID de substância PubChem:
24898256
NACRES:
NA.26

forma

pellets

proporção de alimentação

lactide:glycolide (75:25)

peso molecular

66,000-107,000

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OCC(O)=O.CC(O)C(O)=O

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Descrição geral

The product is an amorphous solid with a transition temperature (Tg) in the range of 45-50°C. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.

Aplicação

Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics.

Características e benefícios

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

forma física

Biocompatible, biodegradable polymer.

Informações legais

Lactel is a registered trademark of Evonik Corp

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo
Werner E.G.Muller
Acta Biomaterialia, 50, 89-101 (2017)
Robert M Stefani et al.
Acta biomaterialia, 102, 326-340 (2019-12-06)
Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
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