P0021

Pantoprazole sodium hydrate

≥98% (HPLC)

• Sinônimo(s): 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate
• Fórmula empírica (Notação de Hill): C₁₆H₁₄F₂N₃O₄S · Na · xH₂O
• Número CAS: 718635-09-7
• Peso molecular: 405.35 (anhydrous basis)
• Código UNSPSC: 12352203
• ID de substância PubChem: 329819976
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• cor: white to off-white
• solubilidade: H₂O: ≥20 mg/mL
• originador: Novartis
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
• InChI: 1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;
• chave InChI: CGJRLPRCWSHOFU-UHFFFAOYSA-N
• Informações sobre genes: human ... ATP4A(495) , ATP4B(496)

Descrição

Aplicação

Pantoprazole sodium hydrate has been used:

• as a standard in high-performance liquid chromatography (HPLC){58
• as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
• to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Ações bioquímicas/fisiológicas

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.

Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.

Pantoprazole is a gastric proton pump inhibitor.

Características e benefícios

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable