O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Sinônimo(s): (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
• Fórmula empírica (Notação de Hill): C₂₉H₅₃NO₅
• Número CAS: 96829-58-2
• Peso molecular: 495.73
• Número MDL: MFCD05662360
• Código UNSPSC: 41106300
• ID de substância PubChem: 24724564
• NACRES: NA.77

Propriedades

• product name: Orlistat, ≥98%, solid
• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Ensaio: ≥98%
• forma: solid
• cor: white
• pf: <50 °C
• solubilidade: DMSO: 19 mg/mL
• originador: Roche
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• chave InChI: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Informações sobre genes: human ... LIPF(8513) , PNLIP(5406)

Descrição

Descrição geral

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Aplicação

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Ações bioquímicas/fisiológicas

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Características e benefícios

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

Solution is not completely clear, small particles may remain floating.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)