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B1552

Sigma-Aldrich

Bromoenol lactone

≥98% (TLC)

Sinônimo(s):

BEL, E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one

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About This Item

Fórmula empírica (Notação de Hill):
C16H13BrO2
Número CAS:
88070-98-8
Peso molecular:
317.18
Número MDL:
MFCD00270871
Código UNSPSC:
41106300
ID de substância PubChem:
24278257
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥98% (TLC)

forma

powder

potência

636 nM Ki

solubilidade

DMSO: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)
degassed ethanol: soluble (Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.)

λmax

224 nm

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H]\C(Br)=C1\CCC(C(=O)O1)c2cccc3ccccc23

InChI

1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+

chave InChI

BYUCSFWXCMTYOI-ZRDIBKRKSA-N

Ações bioquímicas/fisiológicas

Potent, irreversible inhibitor of calcium-independent phospholipase A2 and of magnesium-dependent phosphatidate phosphohydrolase from P388D macrophages (IC50 = 8 μM); enzyme activated irreversible chymotrypsin inhibitor (Ki = 636 nM).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Atglistatin ≥98% (HPLC)

Sigma-Aldrich

SML1075

Atglistatin

Aristolochic acid I powder

Sigma-Aldrich

A5512

Aristolochic acid I

Orlistat ≥98%, solid

Sigma-Aldrich

O4139

Orlistat

(±)-Propranolol hydrochloride ≥99% (TLC), powder

Sigma-Aldrich

P0884

(±)-Propranolol hydrochloride

Ulrika Christerson et al.
Cells, 8(7) (2019-07-07)
Increased activity of secretory phospholipases A2 (sPLA2) type-II was previously observed in ileum of Crohn's disease (CD). Our aims were to explore the involvement of calcium-independent (i)PLA2β in the release of sPLA2s from the human mast cell (MC) line (HMC-1)
Masahiro Nagahama et al.
Toxins, 10(5) (2018-05-23)
Clostridium perfringens iota-toxin is a binary actin-ADP-ribosylating toxin composed of the enzymatic component Ia and receptor binding component Ib. Ib binds to a cell surface receptor, forms Ib oligomer in lipid rafts, and associates with Ia. The Ia-Ib complex then
Jesús E Villanueva et al.
Nature communications, 10(1), 2700-2700 (2019-06-22)
Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and
Kasey K Pham et al.
Genome, 60(9), 720-732 (2017-04-27)
Owing to high rates of introgressive hybridization, the plastid genome is poorly suited to fine-scale DNA barcoding and phylogenetic studies of the oak genus (Quercus, Fagaceae). At the tips of the oak plastome phylogeny, recent gene migration and reticulation generally
Vincenzo Lariccia et al.
The Journal of general physiology, 137(1), 111-132 (2010-12-29)
We describe rapid massive endocytosis (MEND) of >50% of the plasmalemma in baby hamster kidney (BHK) and HEK293 cells in response to large Ca transients. Constitutively expressed Na/Ca exchangers (NCX1) are used to generate Ca transients, whereas capacitance recording and
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Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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