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A8054

Sigma-Aldrich

D(−)-2-Amino-5-phosphonopentanoic acid

NMDA receptor antagonist

Sinônimo(s):

D(−)-AP-5, D(−)-APV, D-2-Amino-5-phosphonovaleric acid

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About This Item

Fórmula empírica (Notação de Hill):
C5H12NO5P
Número CAS:
79055-68-8
Peso molecular:
197.13
Número MDL:
MFCD00078839
Código UNSPSC:
12352106
ID de substância PubChem:
24891311
NACRES:
NA.26

Ensaio

≥98% (TLC)

forma

powder

pureza óptica

optical purity: ≥90% (HPLC, Marfey′s reagent)

técnica(s)

ligand binding assay: suitable

cor

white

pf

245-246 °C

cadeia de caracteres SMILES

N[C@H](CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1

chave InChI

VOROEQBFPPIACJ-SCSAIBSYSA-N

Informações sobre genes

mouse ... Grin2a(14811)
rat ... Grik1(29559) , Grin2a(24409) , Grin2b(24410) , Grin2c(24411) , Grin2d(24412)

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Categorias relacionadas

Aplicação

D(-)-2-Amino-5-phosphonopentanoic acid has been used to pretreat BNST (bed nucleus of the stria terminalis) in order to block the induction of anxiety by ORX-A (orexin-A) into the BNST.

Ações bioquímicas/fisiológicas

NMDA antagonists have muscle relaxation property and are known to offer neuron protection against brain damage induced by ischemia. 2-Amino-5-phosphonopentanoic acid has been proved to block the iontophoresis induced depolarization of NMDA.
Anticonvulsant; potent and selective N-methyl-D-aspartate (NMDA) receptor antagonist; active enantiomer of 2-amino-5-phosphonopentanoic acid.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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