N0290

Nitazoxanide

≥98% (HPLC)

• Sinônimo(s): NTZ; 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
• Fórmula empírica (Notação de Hill): C₁₂H₉N₃O₅S
• Número CAS: 55981-09-4
• Peso molecular: 307.28
• Número CE: 259-931-8
• Número MDL: MFCD00416599
• Código UNSPSC: 12352200
• ID de substância PubChem: 329818424
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• originador: Romark
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
• InChI: 1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
• chave InChI: YQNQNVDNTFHQSW-UHFFFAOYSA-N

Descrição

Descrição geral

Nitazoxanide (NTZ), a thiazolide compound[1] is a antiparasitic drug with structure similar to niclosamide.[2]

Aplicação

Nitazoxanide has been used:

• to test its anti-viral activity against chikungunya virus[3]
• as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines[4]
• to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells[5]

Ações bioquímicas/fisiológicas

Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways[5] and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria.[2] It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies.[3] NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV).[3] It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.[1]

Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria.

Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Características e benefícios

This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable