M9020

Mecamylamine hydrochloride

≥98% (TLC), powder, nAChR antagonist

• Sinônimo(s): 2-(Methylamino)isocamphane hydrochloride, Inversine, N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
• Fórmula empírica (Notação de Hill): C₁₁H₂₁N · HCl
• Número CAS: 826-39-1
• Peso molecular: 203.75
• Número CE: 212-555-8
• Número MDL: MFCD00151462
• Código UNSPSC: 12352116
• ID de substância PubChem: 24277851
• NACRES: NA.77

Propriedades

• Nome do produto: Mecamylamine hydrochloride,
• Formulário: powder
• Nível de qualidade: 200
• solubilidade: ethanol: 122 mg/mL; H₂O: 47 mg/mL; isopropanol: 476 mg/mL; glycerol: 95 mg/mL
• originador: AstraZeneca
• cadeia de caracteres SMILES: Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1
• chave InChI: PKVZBNCYEICAQP-CIISUUNXSA-N
• Informações sobre genes: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

Descrição

Aplicação

Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.

Ações bioquímicas/fisiológicas

Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Atenção

Solutions are stable to autoclaving.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves