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M0880

Sigma-Aldrich

Ethyl methanesulfonate

liquid

Sinônimo(s):

Ethyl mesylate, Methanesulfonic acid ethyl ester

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About This Item

Fórmula linear:
CH3SO3CH2CH3
Número CAS:
62-50-0
Peso molecular:
124.16
Beilstein:
773969
Número CE:
200-536-7
Número MDL:
MFCD00007559
Código UNSPSC:
12352108
ID de substância PubChem:
24896575
NACRES:
NA.25

forma

liquid

índice de refração

n20/D 1.418 (lit.)

pb

85-86 °C/10 mmHg (lit.)

densidade

1.206 g/mL at 20 °C

cadeia de caracteres SMILES

CCOS(C)(=O)=O

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

chave InChI

PLUBXMRUUVWRLT-UHFFFAOYSA-N

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Aplicação

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Ações bioquímicas/fisiológicas

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

212.0 °F

Ponto de fulgor (°C)

100 °C

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

C9754

Colchicina

Establishment of a human somatic hybrid cell line for recombinant protein production
Cho MS, et al.
Journal of Biomedical Science, 9(6), 631-638 (2002)
Scanning ethyl methanesulphonate effects on the whole genome of Lotus japonicus using second generation sequencing analysis
Mohd-Yusoff NF, et al.
G3 (Bethesda, Md.), g3-114 (2015)
Kade M Power et al.
PLoS genetics, 16(10), e1009052-e1009052 (2020-10-17)
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elegans, mutations
Novel wine yeast with ARO4 and TYR1 mutations that overproduce `floral?aroma compounds 2-phenylethanol and 2-phenylethyl acetate
Cordente AG, et al.
Applied Microbiology and Biotechnology, 1-12 (2018)
Genotoxicity Effect of Ethyl Methanesulfonate on Root Tip Cells of Chilli (Capsicum annuum L.)
Devi AS and Mullainathan L
World Journal of Agricultural Sciences, 7(4), 368-374 (2011)
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