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L7647

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

Type VI, lyophilized powder

Sinônimo(s):

Con A

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About This Item

Número CAS:
11028-71-0
Número CE:
234-258-2
Número MDL:
MFCD00071069
Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

Canavalia ensiformis

tipo

Type VI

forma

lyophilized powder

potência

≤20 μg per mL agglutination activity

Impurezas

Carbohydrate, essentially free
 salt, essentially free

solubilidade

water: 1 % (w/v)

temperatura de armazenamento

−20°C

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Categorias relacionadas

Aplicação

Concanavalin A from Canavalia ensiformis (Jack bean) has been used for developing zwitterion-immobilized molecularly imprinted polymers (ziMIPs) for protein crystallization. It has been also used in the preparation of protein loaded microgels to prevent enzymatic degradation of microgels for monitoring by confocal laser scanning microscope (CLSM).

Ações bioquímicas/fisiológicas

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Nota de preparo

Highly purified by specific affinity chromatography.

Nota de análise

Agglutination activity: Determined from serial dilutions of a 1 mg/mL solution (this activity is the lowest conc. to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C). Requires Type A Human Blood.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H317,H334,H361

Classificações de perigo

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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