I5395
Anti-Interleukin-12 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Sinônimo(s):
Anti-IL-12
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About This Item
Produtos recomendados
fonte biológica
goat
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
lyophilized powder
reatividade de espécies
human
técnica(s)
neutralization: suitable
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... IL12A(3592)
Descrição geral
Interleukin-12 (IL-12) is an important cytokine that links innate and adaptive immunity. It plays a role in the regulation of Th1-associated cellular immunity to foreign pathogens, and humoral immunity to antigens that are both T cell-independent and T cell-dependent. IL-12 is primarily produced by innate immune cells, dendritic cells, epithelial cells and macrophages. All forms of IL-12 bind to the IL-12R which includes IL-12RbI and IL-12RbII subunits expressed on T cells and natural cells. IL-12 stimulates the production of IFN-γ and TNF-α, subsequent production of nitric oxide that leads to pathogen destruction. Reports suggest the involvement of JAK/STAT pathway components in mediating these effects. The effects of IL-12 have been implicated in bacterial, fungal and viral infections. Due to its role in inducing matrix metalloproteases, it also has important role in the etiology of chronic B-cell malignancies and lung adenocarcinomas
Anti-Interleukin-12 antibody recognizes human IL-12.
Anti-Interleukin-12 antibody recognizes human IL-12.
Especificidade
The antibody neutralizes the biological activity of recombinant human IL-12.
Imunogênio
recombinant human IL-12 expressed in Sf 21 insect cells.
Aplicação
Anti-Interleukin-12 antibody may be used for ELISA at a working antibody concentration of 0.5 μg/ml. For immunoblotting, a working concentration of 1 μg/ml is recommended. The antibody is also suitable for neutralization reactions.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Nota de preparo
Purified using protein G.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Dennis W Metzger
Cytokine, 52(1-2), 102-107 (2010-07-24)
Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine
Anne O'Garra et al.
Nature immunology, 10(9), 929-932 (2009-08-21)
The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.
IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
Ashman RB et al
Clinical & Developmental Immunology, doi: 10-doi: 10 (2011)
David J Klinke
Molecular cancer, 9, 242-242 (2010-09-17)
Monoclonal antibodies represent some of the most promising molecular targeted immunotherapies. However, understanding mechanisms by which tumors evade elimination by the immune system of the host presents a significant challenge for developing effective cancer immunotherapies. The interaction of cancer cells
John L Langowski et al.
Nature, 442(7101), 461-465 (2006-05-12)
Chronic inflammation has long been associated with increased incidence of malignancy and similarities in the regulatory mechanisms have been suggested for more than a century. Infiltration of innate immune cells, elevated activities of matrix metalloproteases and increased angiogenesis and vasculature
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