I2286

Irbesartan

≥98% (HPLC), powder

• Sinônimo(s): 2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, Avapro, BMS-186295, SR-47436
• Fórmula empírica (Notação de Hill): C₂₅H₂₈N₆O
• Número CAS: 138402-11-6
• Peso molecular: 428.53
• Número MDL: MFCD00864464
• Código UNSPSC: 12352200
• ID de substância PubChem: 329815365
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: DMSO: >25 mg/mL
• originador: Bristol-Myers Squibb; Sanofi Aventis
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5
• InChI: 1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)
• chave InChI: YOSHYTLCDANDAN-UHFFFAOYSA-N
• Informações sobre genes: human ... AGTR1(185)

Descrição

Descrição geral

Irbesartan comprises bipentyl-tetrazole side chain. It is an imidazole derivative with high bioavailability and is metabolized by the enzyme cytochrome P450 2C9 isoenzyme in liver to be majorly eliminated by oxidation and glucuronidation.[1]

Aplicação

Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue.[2][3][4] It may be used to test its effect on allergic asthma in rat and mice mast cells.[5]

Ações bioquímicas/fisiológicas

Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity.[1] It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties.[1] Irbesartan shows protective cardiovascular effects[1] and provides protection against chronic glomerulonephritis.[5]

Características e benefícios

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable