SML0432

Azilsartan

≥98% (HPLC)

• Sinônimo(s): 1-[[2′-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl) [1,1′-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid, 2-Ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid, TAK-536
• Fórmula empírica (Notação de Hill): C₂₅H₂₀N₄O₅
• Número CAS: 147403-03-0
• Peso molecular: 456.45
• Número MDL: MFCD00916395
• Código UNSPSC: 12352200
• ID de substância PubChem: 329824716
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 15 mg/mL (clear solution)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCOc1nc2cccc(C(O)=O)c2n1Cc3ccc(cc3)-c4ccccc4C5=NC(=O)ON5
• InChI: 1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
• chave InChI: KGSXMPPBFPAXLY-UHFFFAOYSA-N
• Informações sobre genes: human ... AGTR1(185)

Descrição

Ações bioquímicas/fisiológicas

Azilsartan is a highly potent and slowly dissociating Angiotensin II type 1 (AT1) receptor blocker (ARB) with an IC₅₀ of 2.6 nM. It is the active form of Azilsartan medoxomil, used for treatment of hypertension. Azilsartan may also have potentially beneficial effects on metabolic syndrome including insulin sensitizing activity that may involve more than just blockade of AT(1) receptors.

Azilsartan is an Angiotensin II receptor blocker; anti-hypertensive.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable