When prepared in water at 100 mg/mL, this material is expected to be clear to very slightly hazy in solution. While there is no specification for the color,
historical records indicate a range of faint yellow to light brown in solution.
H9523
Serotonin hydrochloride
Serotonin hydrochloride
1 of 2 reviewers received a sample product or took part in a promotion
≥98%, powder, neurotransmitter
Sinônimo(s):
3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
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About This Item
Fórmula empírica (Notação de Hill):
C10H12N2O · HCl
Número CAS:
Peso molecular:
212.68
Beilstein:
3570963
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.
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Nome do produto
Serotonin hydrochloride, powder
Ensaio
≥98%
Nível de qualidade
Formulário
powder
cor
white to off-white
pf
149-154 °C (lit.)
solubilidade
H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
Cl[H].NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
chave InChI
MDIGAZPGKJFIAH-UHFFFAOYSA-N
Informações sobre genes
human ... HTR3A(3359)
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Descrição geral
Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen.[1] It is produced in the axon terminal present in the brain.[2] Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions.[2] It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition.[2] Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.[3]
Aplicação
Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids[4], to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells[5], in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line[6]
Ações bioquímicas/fisiológicas
Neurotransmitter.
Características e benefícios
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota de preparo
Solutions should be freshly prepared.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Oral - Repr. 2
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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Certificados de análise (COA)
Lot/Batch Number
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Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Rhian Stavely et al.
Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)
Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious
Artigos
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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Hello, what colour is the solution supposed to be when dissolved? Best, Anaïs
1 answer-
Helpful?
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Can it be stored -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
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What is the purity of Product H9523, Serotonin hydrochloride?
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This product must be at least 98% pure according to our specifications. The purity for individual lots can be found on the certificate of analysis.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Has Product H9523, Serotonin hydrochloride, been cell culture tested?
1 answer-
No. We do not test this product for cell culture suitability.
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What are the storage conditions for Product H9523, Serotonin hydrochloride?
1 answer-
This product is a powder and should be refrigerated at 2-8°C. We do not recommend storing solutions of this product.
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Can I store solutions of Product H9523, Serotonin hydrochloride?
1 answer-
Solutions of this product are unstable. We recommend preparing this solution fresh for each application.
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Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?
1 answer-
This product is the neurotransmitter serotonin. Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.
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