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H7640

Sigma-Aldrich

Heparan sulfate sodium salt from bovine kidney

Heparan sulfate sodium salt from bovine kidney

powder, extracellular matrix component

Sinônimo(s):

Heparitin sulfate sodium salt

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About This Item

Número CAS:
57459-72-0
Número MDL:
MFCD00131294
Código UNSPSC:
12352200
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

Heparan sulfate sodium salt from bovine kidney,

Nível de qualidade

200

temperatura de armazenamento

2-8°C

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Aplicação

Heparan sulfate sodium salt from bovine kidney has been used:
  • to investigate its effect on proliferation of B cells[1]
  • to monitor its role on eye development in E5 embryonic cells[2]
  • to study its binding with exosome fibronectin in human trabecular meshwork cells using dot blot[3]

Ações bioquímicas/fisiológicas

Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars.[4] It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units.[5] It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression.[6] HS is associated with the onset of infectious diseases and inflammatory conditions.[7] HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.[8]Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000408090
0000399946
0000399947
0000393339
0000369870

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Change in embryonic eye size and retinal cell proliferation following intravitreal injection of glycosaminoglycans
Halfter W
Investigative Ophthalmology & Visual Science, 49(8), 3289-3298 (2008)
Mechanism of fibronectin binding to human trabecular meshwork exosomes and its modulation by dexamethasone
Dismuke WM, et al.
Testing, 11(10), e0165326-e0165326 (2016)
Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression
Nagarajan A, et al.
Frontiers in Endocrinology, 9(4), 203-231 (2018)
Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer?s disease
Zhang GL, et al.
BioMed Research International, 2014(6), 555-571 (2014)
Y Tanaka et al.
The Journal of experimental medicine, 184(5), 1987-1997 (1996-11-01)
Leukocyte migration from circulation into tissue depends on leukocyte integrin-mediated adhesion to endothelium, but integrins cannot function until activated. However, it remains to be understood how tumor cells adhere to endothelium and infiltrate into underlying tissue. We studied mechanisms of
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2 Reviews This action will navigate to reviews.

Questions

1–2 of 2 Questions  

  1. What solvent should i use to dissolve this?

    1 answer

    1. The solubility of this item is 1mg/ml as mentioned on the COA.
      Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdf

      Helpful?

  2. Wo finde ich eine Angabe zum Molekulargewicht?

    1 answer

    1. The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.

      Helpful?

Reviews

Active Filters

  1. Switzerland
    • Review 1
    • Votes 0
    1 out of 5 stars.

    -

    Insufficient info on concentration on data sheet to know how much you are using

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for reaching out and sharing your review with us. Heparan Sulfate is a polysaccharide with a variable molecular weight. We do not provide a quantitative purity value for this product, however it is used as a substrate in testing of our Heparinase III product, H8891. We report the sulfur content on the lot-specific Certificate of Analysis. The molecular weight range of this product is 10 - 14 dDa. For further discussion, we welcome you to contact our Technical Service team by visiting https://www.sigmaaldrich.com/support/customer-support and submitting a Product Technical Inquiry. We hope to hear from you soon!

  2. 1 Ratings-Only Review

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