Heparin Cofactor II (HCII) is a member of the serpin superfamily and acts as a serine protease inhibitor. It rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. However, it should be noted that Heparin Cofactor II itself is not a proper anticoagulant. When used alone, it will not prevent blood from coagulating. For anticoagulant purposes, substances such as Heparin sodium salt, EDTA, or Sodium Citrate are commonly used in research and clinical laboratories.
H0417
Heparin Cofactor II from human plasma
aqueous glycerol solution, ≥90% (SDS-PAGE)
Sinônimo(s):
HCF2, HCII, SERPIND1
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About This Item
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fonte biológica
human plasma
Nível de qualidade
Ensaio
≥90% (SDS-PAGE)
Formulário
aqueous glycerol solution
peso molecular
~66 kDa
~66 kDa
nº de adesão NCBI
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... SERPIND1(3053)
Ações bioquímicas/fisiológicas
Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.
Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.
Definição da unidade
HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.
forma física
50% aqueous glycerol solution (vol/vol)
Exoneração de responsabilidade
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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