Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

G7048

Sigma-Aldrich

Proguanil hydrochloride

≥95% (HPLC)

Sinônimo(s):

Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C11H16ClN5·HCl
Número CAS:
637-32-1
Peso molecular:
290.19
Número CE:
211-283-7
Número MDL:
MFCD01732193
Código UNSPSC:
51101906
ID de substância PubChem:
329799959
NACRES:
NA.77

Ensaio

≥95% (HPLC)

forma

solid

condição de armazenamento

desiccated

solubilidade

acetonitrile: water: ~1 mg/mL (60/40)

originador

AstraZeneca

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1

InChI

1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

chave InChI

SARMGXPVOFNNNG-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Aplicação

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Ações bioquímicas/fisiológicas

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Características e benefícios

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 8

1 of 8

2’-C-Methylcytidine ≥95% (HPLC), powder

Sigma-Aldrich

M4949

2′-C-Methylcytidine

Chlorhexidine dihydrochloride ≥98%

Sigma-Aldrich

C8527

Chlorhexidine dihydrochloride

Sumatriptan succinate ≥98% (HPLC), solid

Sigma-Aldrich

S1198

Sumatriptan succinate

Atovaquone Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1591

Atovaquone

Chlorhexidine diacetate salt hydrate bis(biguanide) antimicrobial

Sigma-Aldrich

C6143

Chlorhexidine diacetate salt hydrate

Arbidol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0860

Arbidol hydrochloride

Amodiaquin dihydrochloride dihydrate analytical standard

Supelco

A2799

Amodiaquin dihydrochloride dihydrate

Pyrimethamine VETRANAL®, analytical standard

Supelco

46706

Pyrimethamine

Olivier Bouchaud et al.
Malaria journal, 11, 212-212 (2012-06-23)
Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was
Patricia Schlagenhauf et al.
Expert review of anti-infective therapy, 10(5), 537-546 (2012-06-19)
The concept of 'standby emergency treatment' (SBET) describes the strategy where travelers carry an emergency malaria treatment for self-administration when no medical attention is available or for use under medical supervision after a confirmed malaria diagnosis, and raises many issues
S Looareesuwan et al.
The American journal of tropical medicine and hygiene, 60(4), 533-541 (1999-05-29)
The continuing spread of drug-resistant malaria emphasizes the need for new antimalarial drugs. Atovaquone is a broad-spectrum antiprotozoal drug with a novel mechanism of action, via inhibition of parasite mitochondrial electron transport, and a favorable safety profile. Early studies with
Sarah Donegan et al.
Statistics in medicine, 31(29), 3840-3857 (2012-07-13)
Mixed treatment comparison (MTC) meta-analysis allows several treatments to be compared in a single analysis while utilising direct and indirect evidence. Treatment by covariate interactions can be included in MTC models to explore how the covariate modifies the treatment effects.
Carine Van Malderen et al.
Malaria journal, 11, 139-139 (2012-05-02)
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy
Exibir todos os documentos relacionados

Artigos

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica