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F5384

Sigma-Aldrich

Anti-Human IgM (μ-chain specific)−FITC antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Goat Anti-Human IgM (μ-chain specific)−Fluorescein isothiocyanate

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About This Item

Número MDL:
MFCD00162462
Código UNSPSC:
12352203
NACRES:
NA.46

fonte biológica

goat

conjugado

FITC conjugate

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

secondary antibodies

clone

polyclonal

forma

buffered aqueous solution

técnica(s)

direct immunofluorescence: 1:32

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

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Descrição geral

The product binds human IgM; but does not bind other human Igs.

Aplicação

Anti-Human IgM (μ-chain specific)-FITC antibody produced in goat was used as secondary antibody in serodiagnosis of Lyme disease based on seroreactivity against Borrelia spirochaetes.

Ações bioquímicas/fisiológicas

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Nayoung Ko et al.
Scientific reports, 12(1), 9611-9611 (2022-06-11)
Pig-to-human organ transplantation is a feasible solution to resolve the shortage of organ donors for patients that wait for transplantation. To overcome immunological rejection, which is the main hurdle in pig-to-human xenotransplantation, various engineered transgenic pigs have been developed. Ablation
Julia Hennicke et al.
New biotechnology, 50, 20-26 (2019-01-11)
IgM antibodies are arousing considerable interest as biopharmaceuticals. Despite their immunotherapeutic potential, little is known about the impact of environmental conditions on product quantity and quality of these complex molecules. Process conditions influence the critical quality attributes (CQAs) of therapeutic
J C Magee et al.
The Journal of clinical investigation, 96(5), 2404-2412 (1995-11-01)
Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation versus control in a pig-to-primate
Clayton A White et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5933-5950 (2014-11-14)
Class-switch DNA recombination (CSR) and somatic hypermutation (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires B lymphocyte-induced maturation protein-1 (Blimp-1), are critical for the generation of class-switched and hypermutated (mature) Ab and autoantibody responses. We
Jingtao Cui et al.
PloS one, 13(11), e0206995-e0206995 (2018-11-08)
Chlamydia pneumoniae (C. pneumoniae) is an obligate intracellular bacterium and a human pathogen that causes respiratory infectious diseases. More than 50% of the adult population worldwide was once infected with C. pneumoniae, but investigations into this topic are insufficient in
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