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D6513

Sigma-Aldrich

Desmosterol

≥84% (GC)

Sinônimo(s):

24-Dehydrocholesterol, 3β-Hydroxy-5,24-cholestadiene, 5,24-Cholestadien-3β-ol

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R$ 780,00
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R$ 780,00
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About This Item

Fórmula empírica (Notação de Hill):
C27H44O
Número CAS:
313-04-2
Peso molecular:
384.64
Número CE:
206-236-2
Número MDL:
MFCD00056432
Código UNSPSC:
12352200
ID de substância PubChem:
24894033
NACRES:
NA.77

R$ 780,00

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Ensaio

≥84% (GC)

Formulário

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC=C(C)C

InChI

1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

chave InChI

AVSXSVCZWQODGV-DPAQBDIFSA-N

Descrição geral

Desmosterol is a C27 sterol intermediate in cholesterol synthesis. It may be associated with the pathogenesis of Alzheimer′s disease (AD).[1]

Aplicação

Desmosterol has been used as a standard for the estimation of the concentrations of cholesterol and plant sterols.[2][3] It has also been used to suppress nigericin-induced sterol regulatory element-binding proteins 2 (SREBP2) maturation.[4]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000406770
0000359254
0000356692
0000356690
0000324221

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Ana Rita Lima et al.
Metabolites, 8(1) (2018-03-23)
Prostate cancer (PCa) is an important health problem worldwide. Diagnosis and management of PCa is very complex because the detection of serum prostate specific antigen (PSA) has several drawbacks. Metabolomics brings promise for cancer biomarker discovery and for better understanding
Clare L Beasley et al.
Bipolar disorders, 7(5), 449-455 (2005-09-24)
Cholesterol forms an integral part of cell membranes and is a major component of myelin. Furthermore, cholesterol also plays a vital role in the development, function and stability of synapses. While low serum cholesterol has previously been associated with mood
Anti-atherogenic effects of phytosteryl oleates in apo-E deficient mice
Moghadasian MH, et al
Journal of functional foods, 21, 97-103 (2016)
Tim Vanmierlo et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 66(2), 149-156 (2011-03-25)
Plant sterols such as sitosterol and campesterol are frequently applied as functional food in the prevention of atherosclerosis. Recently, it became clear that plasma derived plant sterols accumulate in murine brains. We questioned whether plant sterols in the brain are
Arjan Boerke et al.
Biology of reproduction, 88(1), 21-21 (2012-11-02)
This study demonstrates for the first time that porcine and mouse sperm incubated in capacitation media supplemented with bicarbonate produce oxysterols. The production is dependent on a reactive oxygen species (ROS) signaling pathway that is activated by bicarbonate and can
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