D1413

2′,3′-Didehydro-3′-deoxythymidine

≥98% (TLC)

• Sinônimo(s): 1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine, 1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-(1H,3H)-dione, 2′,3′-Anhydrothymidine, Stavudine, d4T
• Fórmula empírica (Notação de Hill): C₁₀H₁₂N₂O₄
• Número CAS: 3056-17-5
• Peso molecular: 224.21
• Número MDL: MFCD00132921
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278356
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• forma: powder
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC1=CN([C@@H]2O[C@H](CO)C=C2)C(=O)NC1=O
• InChI: 1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1
• chave InChI: XNKLLVCARDGLGL-JGVFFNPUSA-N

Descrição

Descrição geral

2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.

Aplicação

2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment. It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity. It has also been used in the preclinical evaluation of GS-9160.

Ações bioquímicas/fisiológicas

2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)