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C8849

Sigma-Aldrich

α-Chloralose−HBC complex

≥92% α-anomer basis

Sinônimo(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose: 2-hydroxypropyl-β-cyclodextrin complex

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥92% α-anomer basis

forma

powder

prazo de validade

4 weeks at 4 °C (for aqueous solutions)

solubilidade

H2O: freely soluble

Aplicação

α-Chloralose-HBC complex has been used for anesthetizing rats for various in vivo studies.

Ações bioquímicas/fisiológicas

α-Chloralose-HBC complex is a preferred anesthetic over isoflurane as it displays no intrusion retinal spreading depolarization (rSD) generation and propagation.

Qualidade

α-Chloralose content: 10% (w/w)

Pictogramas

Environment
GHS09

Palavra indicadora

Warning

Frases de perigo

H410

Declarações de precaução

P273 - P391 - P501

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type N95 (US)

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Tess E Kornfield et al.
eNeuro, 2(2) (2015-06-18)
Blood flow is a useful indicator of the metabolic state of the retina. However, accurate measurement of retinal blood flow is difficult to achieve in practice. Most existing optical techniques used for measuring blood flow require complex assumptions and calculations.
Anja I Srienc et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(9), 1579-1591 (2016-07-09)
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known
Kyle R Biesecker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(36), 9435-9445 (2016-09-09)
The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca(2+) increases in glial cells, triggering glial release of vasodilating agents. This
J Silverman et al.
Laboratory animal science, 43(3), 210-216 (1993-06-01)
Chloral hydrate (CH) and alpha-chloralose (CS) are often used to anesthetize laboratory animals although, to our knowledge, there have been no controlled studies of their anesthetic or analgesic effects. Induction of and recovery from anesthesia can be stressful, and anesthesia
Tess E Kornfield et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11504-11513 (2014-08-22)
Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional

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