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Documentos Principais

C7956

Sigma-Aldrich

Coenzyme Q1

≥95%

Sinônimo(s):

2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5

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2 MG
R$ 874,00
10 MG
R$ 2.987,00
5 X 10 MG
R$ 7.637,00

R$ 874,00


Disponível para enviar em03 de abril de 2025Detalhes



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2 MG
R$ 874,00
10 MG
R$ 2.987,00
5 X 10 MG
R$ 7.637,00

About This Item

Fórmula empírica (Notação de Hill):
C14H18O4
Número CAS:
Peso molecular:
250.29
Número MDL:
Código UNSPSC:
12352204
ID de substância PubChem:
NACRES:
NA.51

R$ 874,00


Disponível para enviar em03 de abril de 2025Detalhes


Ensaio

≥95%

Formulário

liquid

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O

InChI

1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3

chave InChI

SOECUQMRSRVZQQ-UHFFFAOYSA-N

Descrição geral

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.[1]

Aplicação

Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.[2][3][4][5]

Ações bioquímicas/fisiológicas

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

Outras notas

Analog of coenzyme Q10 (not naturally occurring)

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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P G Elmberger et al.
Lipids, 24(11), 919-930 (1989-11-01)
An effective system for perfusing rat liver using complete tissue culture medium and washed calf erythrocytes as oxygen carriers was devised. Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period.
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for
Lee R Swem et al.
The Journal of biological chemistry, 281(10), 6768-6775 (2006-01-13)
Rhodobacter capsulatus regulates many metabolic processes in response to the level of environmental oxygen and the energy state of the cell. One of the key global redox regulators of the cell's metabolic physiology is the sensor kinase RegB that controls
Giancarlo A Biagini et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8298-8303 (2012-05-09)
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure
Coenzyme Q cytoprotective mechanisms.
Tom S Chan et al.
Methods in enzymology, 382, 89-104 (2004-03-30)

Questions

1–2 of 2 Questions  
  1. What is the concentration?

    1 answer
    1. Product C7956 may present as a viscous liquid. Although a specific density has not been assigned due to the product being packaged by weight, there is a predicted density for this compound which is approximately 1.10 ±0.1 g/mL. This implies that for every 10 mg of material, the volume is expected to be around 9.1 µL. The molecular weight of this product is 250.29 g/mol, resulting in a concentration of roughly 4.39 M.

      Helpful?

  2. Hi, I use CoQ1 for COX I enzyme activity assay. Can this Coenzyme Q1(C7956) dissolve in water?

    1 answer
    1. We have only tested this item's solubility in acetone at 50 mg/ml. Upon further research, this item looks to be poorly soluble in water.

      Helpful?

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