C6617

CBIQ

≥98% (HPLC), solid

• Sinônimo(s): 4-Chlorobenzo[f]isoquinoline
• Fórmula empírica (Notação de Hill): C₁₃H₈NCl
• Número CAS: 32081-28-0
• Peso molecular: 213.66
• Número MDL: MFCD02179769
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724450
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• cor: off-white
• solubilidade: DMSO: 15 mg/mL
• cadeia de caracteres SMILES: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
• chave InChI: SHQLTRRYZVBEMR-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Características e benefícios

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS06,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H301,H315,H318,H335
• Declarações de precaução: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classificações de perigo: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges