Pular para o conteúdo
Merck
Todas as fotos(5)

Documentos

C6417

Sigma-Aldrich

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse

clone LDS-68, ascites fluid

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(5)

About This Item

Número MDL:
MFCD00162253
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

LDS-68, monoclonal

contém

15 mM sodium azide

reatividade de espécies

human

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human and animal tissue
microarray: suitable
western blot: suitable

Isotipo

IgG1

nº de adesão UniProt

P08729

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... KRT7(3855)

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Keratin, type II cytoskeletal 7 is a protein encoded by the KRT7 gene in humans. It is also known as cytokeratin-7 (CK-7), keratin-7 (K7), sarcolectin (SCL) and K2C7. Keratin 7 is a type II keratin and is a member of the keratin gene family. It is found on chromosome 12. It is specifically expressed in the simple epithelia lining of the internal organs and in the gland ducts as well as blood vessels.
Monoclonal anti-Cytokeratin Peptide 7 (mouse IgG1 isotype) is derived from the hybridoma produced the fusion of mouse myeloma cells and splenocytes of an immunized mouse. Cytokeratins are the intermediate filaments of endocrine cells. These proteins belongs to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratin 7 (CK 7/ KRT7) is a low molecular weight cytokeratin. It is present in epithelial tissues of lung, breast and ovary.

Especificidade

The antibody reacts specifically with most simple epithelia but shows no reaction with epithelial cells in the intestine or in the stomach.

Imunogênio

cytoskeletal preparation of the RT4 human bladder carcinoma cell line.

Aplicação

Monoclonal Anti-Cytokeratin Peptide 7 antibody produced in mouse has been used in:
  • immunohistochemical staining
  • western blotting
  • immunohistochemistry
  • immunofluorescence.

Ações bioquímicas/fisiológicas

Cytokeratins may play an important role in transhepatic transport and canalicular secretion. Cytokeratin 7 (CK 7/ KRT7) only stains bile ducts in normal liver, hence it is considered as “bile duct keratin”. CK 7 is widely used in surgical pathology. It acts as a specific marker for mammary and extramammary Paget′s disease.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Yoshiyuki Kasai et al.
Regenerative therapy, 4, 71-77 (2016-03-24)
Autologous oral mucosal epithelial cell sheets have been used for treating epithelial defects such as cornea and esophagus. The cell source of patients' oral mucosal epithelial cell sheet should be examined in normality because it has individual difference. In this
Immunohistology of endocrine tumors
Diagnostic Immunohistochemistry (Masson Publishing), 291-339 (2010)
Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine
Kasai Y, et al.
Regenerative therapy, 4, 71-77 (2016)
M Rosenberg et al.
Cytogenetics and cell genetics, 57(1), 33-38 (1991-01-01)
We have localized the genes which encode the human type II epidermal keratins K5, K6a, and K6b and the simple epithelial keratin K7 (KRT5, KRT6A, KRT6B, and KRT7, respectively) to chromosome 12 using Southern blot analysis of somatic cell hybrids.
Role of cytokeratin intermediate filaments in transhepatic transport and canalicular secretion
Kawahara H, et al.
Hepatology, 11(3), 435-448 (1990)
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica