C3118

CPNQ

≥98% (HPLC), solid

• Sinônimo(s): 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, B2
• Fórmula empírica (Notação de Hill): C₂₀H₁₇ClN₄O₃
• Número CAS: 115687-05-3
• Peso molecular: 396.83
• Número MDL: MFCD02039810
• Código UNSPSC: 12352202
• ID de substância PubChem: 329775023
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: solid
• cor: brown
• solubilidade: H₂O: insoluble <2 mg/mL; DMSO: >5 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(Cl)cc3)c4cccnc14
• InChI: 1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2
• chave InChI: KLNPVNZJCWIQSK-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

CPNQ is a promoter of polyQ and α-synuclein inclusion formation and rescuer of Htt proteosomal dysfunction and α-synuclein toxicity.

Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington′s disease and alpha-synuclein in Parkinson′s disease. The disease-causing proteins can take various conformations and are prone to aggregate and form larger cytoplasmic or nuclear inclusions. CPNQ (B2) was identified as a compound that promotes inclusion formation in cellular models of both Huntington′s disease and Parkinson′s disease. Despite the aggregate-forming specifics the compound prevents huntingtin-mediated proteasome dysfunction and reduces alpha-synuclein-mediated toxicity. These results demonstrate that compounds that increase inclusion formation may actually lessen cellular pathology in both Huntington′s and Parkinson′s diseases, suggesting a therapeutic approach for neurodegenerative diseases caused by protein misfolding. The ability of B2 to prevent toxicity, despite increasing inclusions, suggests that inclusions are beneficial rather than toxic, which will be further explored as the molecular target and mechanism. CPNQ (B2) is a desirable tool for both Huntington′s and Parkinson′s research.

Outras notas

Product is air sensitive.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H315,H319,H335
• Declarações de precaução: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges