C2389

Cerulenin

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

• Sinônimo(s): Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
• Fórmula empírica (Notação de Hill): C₁₂H₁₇NO₃
• Número CAS: 17397-89-6
• Peso molecular: 223.27
• Beilstein: 4140423
• Número CE: 241-424-8
• Número MDL: MFCD00083595
• Código UNSPSC: 51111800
• ID de substância PubChem: 24892323
• NACRES: NA.77

Propriedades

• product name: Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
• fonte biológica: Cephalosporium caerulens
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• forma: powder
• pf: 93 °C
• solubilidade: acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
• InChI: 1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
• chave InChI: PTNNGEBMCNMENY-JIVMHGEESA-N
• Informações sobre genes: human ... FASN(2194)

Descrição

Descrição geral

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

Aplicação

Cerulenin has been used:

• as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
• as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
• as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves