BM0019

BMS-777607

≥98% (HPLC)

• Sinônimo(s): BMS-817378, N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
• Fórmula empírica (Notação de Hill): C₂₅H₁₉ClF₂N₄O₄
• Número CAS: 1025720-94-8
• Peso molecular: 512.89
• Número MDL: MFCD16495773
• Código UNSPSC: 12352200
• ID de substância PubChem: 329774362
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 25 mg/mL, clear
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: ClC1=C(N)N=CC=C1OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F
• InChI: 1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
• chave InChI: VNBRGSXVFBYQNN-UHFFFAOYSA-N
• Informações sobre genes: human ... MET(4233)

Descrição

Ações bioquímicas/fisiológicas

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily with IC₅₀ values of 1.8, 3.9, 4.3, and 1.1 nM, respectively, for Ron, Met, Tyro-3, and AxI kinases. BMS-777607 has been studied in a variety of cancer models and has shown anti-cancer activity, causing increased apoptosis, and decreased proliferation and migration, although it has also been shown to induce polyploidy, which may lead to chemoresistance.

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily.

RON kinase inhibitor (RONi, BMS-777607) decreases recepteur d′origine nantais (RON) signaling. This Met kinase inhibitor represses prostate cancer metastatic phenotype in vitro, induced by hepatocyte growth factor.

Características e benefícios

BMS-777607 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Informações legais

Sold for research purposes only under agreement from BMS.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable