B5264

Kanamycin B sulfate salt

aminoglycoside antibiotic

• Sinônimo(s): Bekanamycin sulfate salt
• Fórmula empírica (Notação de Hill): C₁₈H₃₇N₅O₁₀ · xH₂SO₄
• Peso molecular: 483.51 (free base basis)
• Beilstein: 5235274
• Número MDL: MFCD00078511
• Código UNSPSC: 51281654
• ID de substância PubChem: 24891829
• NACRES: NA.85

Propriedades

• Nível de qualidade: 200
• forma: powder or crystals
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
• InChI: 1S/C18H37N5O10.H2O4S/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18;1-5(2,3)4/h4-18,24-29H,1-3,19-23H2;(H2,1,2,3,4)/t4-,5+,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+;/m0./s1
• chave InChI: YGTPKDKJVZOVCO-KELBJJLKSA-N

Descrição

Descrição geral

Chemical structure: aminoglycoside

Aplicação

Used as a selection agent for cells transformed with kanamycin B (neoR, kanR) resistance gene.

Ações bioquímicas/fisiológicas

Kanamycin B is an aminoglycoside antibiotic that is the 2-amino,2-deoxy-analog of kanamycin A. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasm.

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Nota de preparo

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)