B4313

(E/Z)-BCI hydrochloride

≥98% (HPLC)

• Sinônimo(s): (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one; 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride, NSC 150117 hydrochloride
• Fórmula empírica (Notação de Hill): C₂₂H₂₃NO · HCl
• Número CAS: 95130-23-7
• Peso molecular: 353.89
• Número MDL: MFCD16875416
• Código UNSPSC: 51111800
• ID de substância PubChem: 329773232
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 10 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.O=C1C(=Cc2ccccc2)C(NC3CCCCC3)c4ccccc14
• InChI: 1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H
• chave InChI: JPATUDRDKCLPTI-UHFFFAOYSA-N

Descrição

Aplicação

(E/Z)-BCI hydrochloride has been used:

• to evaluate the role of the Duox-H₂O₂-Dusp6 derepression signaling pathway in heart regeneration[1]
• as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects[2]
• as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells[3]

Ações bioquímicas/fisiológicas

(E/Z)-BCI Hydrochloride is an inhibitor of dual-specificity phosphatase 6 (Dusp6) and Dusp1; hyperactivates FGF signaling.

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable