A9101
Acetylcholine chloride
≥99% (TLC), powder or crystals
Sinônimo(s):
ACh
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About This Item
Fórmula linear:
(CH3)3N+CH2CH2OCOCH3Cl-
Número CAS:
Peso molecular:
181.66
Beilstein:
3571875
Número CE:
Número MDL:
Código UNSPSC:
12352204
ID de substância PubChem:
NACRES:
NA.32
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Nome do produto
Acetylcholine chloride, pkg of 150 mg (per vial)
Ensaio
≥99% (TLC)
Nível de qualidade
Formulário
powder or crystals
embalagem
pkg of 150 mg (per vial)
pf
146-150 °C (lit.)
solubilidade
H2O: soluble
temperatura de armazenamento
room temp
cadeia de caracteres SMILES
[Cl-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
chave InChI
JUGOREOARAHOCO-UHFFFAOYSA-M
Informações sobre genes
human ... CHRM3(1131)
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Descrição geral
Acetylcholine is an important neurotransmitter that plays a critical role in multiple neurological systems. Crucial for neurobiology studies, acetylcholine aids researchers in understanding synaptic transmission. In other forms of research, acetylcholine has an effect and influence on tumor neurobiology for cancer R&D, as well as a variety of other cognitive processes.
Aplicação
For use as a substrate to determine acetylcholinesterase activity. Acetylcholine chloride has been used:
- for standard curve preparation in hestrin assay
- in Protein expression, radioactive ligand binding assay and electrophysiological studies of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBPs)
- as a supplement in extracellular solutions for treating the voltage clamped cells in electrophysiology studies
Ações bioquímicas/fisiológicas
Acetyl choline (ACh) is an essential neurotransmitter in both central and peripheral nervous system. ACh binds to nicotinic acetylcholine receptors (nAChRs) and causes fast excitatory neurotransmission.
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Reconstituição
Reconstituted solution is stable for 2 weeks when stored at 2-8 °C
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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