A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

• Fórmula empírica (Notação de Hill): C₄₅H₈₁N₁₃O₁₄S
• Número CAS: 147740-73-6
• Peso molecular: 1060.27
• Número MDL: MFCD00214225
• Código UNSPSC: 51111800
• ID de substância PubChem: 24890634
• NACRES: NA.32

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥95% (HPLC)
• forma: powder
• nº de adesão UniProt: P05067
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
• chave InChI: IDGOADDOQWKZOX-UHFFFAOYSA-N
• Informações sobre genes: human ... APP(351)

Descrição

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

Descrição geral

Amyloid β precursor protein (APP) is a type-1 transmembrane protein. APP is expressed widely and mainly found in the synapses and neurons. The APP gene is mapped to human chromosome 21q21.3.

Aplicação

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.

Ações bioquímicas/fisiológicas

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis. Amyloid β-Protein Fragment 35-25 is an inactive control.

Outras notas

The N—C inverted sequence of fragment 25-35

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)