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76308

Sigma-Aldrich

Pefabloc® TH

acetate salt, ≥90% (HPLC)

Sinônimo(s):

4-Amidino-Nα-(naphthalene-2-sulfonylglycyl)-DL-phenylalanine-piperidide acetate salt, NAPAP

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About This Item

Fórmula empírica (Notação de Hill):
C27H31N5O4S · C2H4O2
Peso molecular:
581.68
Número MDL:
MFCD01311055
Código UNSPSC:
12352202
ID de substância PubChem:
329767027

fonte biológica

synthetic

Ensaio

≥90% (HPLC)

Formulário

flakes
powder or crystals

cadeia de caracteres SMILES

CC(O)=O.NC(=N)c1ccc(CC(NC(=O)CNS(=O)(=O)c2ccc3ccccc3c2)C(=O)N4CCCCC4)cc1

InChI

1S/C27H31N5O4S.C2H4O2/c28-26(29)21-10-8-19(9-11-21)16-24(27(34)32-14-4-1-5-15-32)31-25(33)18-30-37(35,36)23-13-12-20-6-2-3-7-22(20)17-23;1-2(3)4/h2-3,6-13,17,24,30H,1,4-5,14-16,18H2,(H3,28,29)(H,31,33);1H3,(H,3,4)

chave InChI

ZBMVAFLDTKWMBP-UHFFFAOYSA-N

Informações sobre genes

human ... F2(2147) , PLAT(5327) , PLG(5340) , PRSS1(5644)

Aplicação

Thrombin inhibitor; used in 3-D modeling of snake venom serine proteases to elucidate the differences with thrombin in their inhibitory domains.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações legais

Pefabloc is a registered trademark of Pentapharm

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCBQ3757V
BCBM9435V
BCBM7240V
BCBL9280V

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Gilad Reuveni et al.
Neuroreport, 28(17), 1176-1179 (2017-09-16)
Thrombin is a coagulation factor implicated in various pathological and physiological processes in the brain, exerting beneficial and deleterious effects in a concentration-dependent manner. Measurement of thrombin activity levels in pathological animal models is needed and in some cases, because
Efrat Shavit-Stein et al.
Frontiers in neurology, 9, 1139-1139 (2019-01-22)
Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin
Ekaterina Mindel et al.
Journal of neuroscience research, 99(3), 966-976 (2020-12-10)
Many coagulation factor proteases are increased in the brain during ischemic stroke. One of these proteases is plasmin. In this study we established a novel method for direct quantitative measurement of plasmin activity in male mouse brain slices using a
Alexandra Gerasimov et al.
Neural regeneration research, 16(10), 2086-2092 (2021-03-02)
Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases. Thrombin, a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor, activated protein C (aPC), is considered neuroprotective. While levels of thrombin and aPC activity are
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