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42867

Sigma-Aldrich

Sulfato de dextrana

Mr ~40,000

Sinônimo(s):

Sulfato sódico de dextrano DSS

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5 G
R$ 897,00
25 G
R$ 3.569,00
100 G
R$ 10.261,00

R$ 897,00

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5 G
R$ 897,00
25 G
R$ 3.569,00
100 G
R$ 10.261,00

About This Item

Código UNSPSC:
12352201
NACRES:
NA.25

R$ 897,00

Em estoqueDetalhes

Solicite uma grande encomenda

Formulário

powder

Nível de qualidade

100

peso molecular

Mr ~40,000

perda

≤10% loss on drying

cor

white to off-white

faixa de pH útil

6.0-8 (10 g/L)

pf

(Decomposes on heating.)

solubilidade

water: soluble

temperatura de armazenamento

room temp

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

A dextrana é um polímero de anidroglicose. Ela consiste de cerca de 95% de ligações alfa-D-(166). As demais (163) ligações são responsáveis pela ramificação da dextrana.

Aplicação

O sulfato de dextrana é usado rotineiramente para precipitação seletiva de lipoproteínas, hibridização de sondas a DNA imobilizado em membrana, liberação de DNA de complexos DNA-histona e inibição da ligação de RNA a ribossomos.

Ações bioquímicas/fisiológicas

O tratamento com sulfato sódico de dextrana desencadeia o desenvolvimento de colite em camundongos e ratos por meio da sua ligação aos ácidos graxos de cadeia média presentes no cólon e induz inflamação. [1]

Outras notas

Para obter uma compreensão abrangente de nossa ampla gama de dextranas para sua pesquisa, recomendamos que você visite nossa página de categoria decarboidratos.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCM3019
BCCL8105
0000280330
0000284126
0000273418

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

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Slide 1 of 7

1 of 7

Sulfato de dextrana avg mol wt >500,000 (dextran starting material)

Sigma-Aldrich

D8787

Sulfato de dextrana

Sulfato de dextrana Mr ~500,000

Sigma-Aldrich

31395

Sulfato de dextrana

Sulfato de dextrana average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8

Sigma-Aldrich

D6001

Sulfato de dextrana

Sigma-Aldrich

Sigma-Aldrich

78331

FITC-Dextran sulfate sodium salt

Sulfato de dextrana average mol wt 9,000-20,000

Sigma-Aldrich

D6924

Sulfato de dextrana

Dextran Sulfate 50% Solution

Millipore

S4030

Dextran Sulfate 50% Solution

Dextran Sulfate 50% Solution

Millipore

S4031

Dextran Sulfate 50% Solution

Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
N Facchinello et al.
Scientific reports, 7(1), 4371-4371 (2017-07-01)
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does DDS (Dextran Sodium Sulfate) come in a USP grade for a animal studies?

    1 answer

    1. Unfortunately, there is no pharmaceutical grade Dextran Sodium Sulfate available at this time. This product is not tested for use in animal models. It would be up to the researcher to determine suitability.

      Helpful?

  4. Hello! I want to know if you can autoclave water with 4% of dextran sulfate sodium (DSS) without decomposing the DSS.

    1 answer

    1. The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ions. The calcium salt of dextran sulfate is insoluble. The free acid (hydrogen) form of dextran sulfate is extremely acidic and autohydrolyzes rapidly in solution and as a powder.

      More information can be found here: https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/protein-pulldown/dextran-sulfate

      Helpful?

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