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A5486

Azoximetano

13.4 M, ≥98%

Sinônimo(s):

AOM

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Sobre este item

Fórmula linear:
CH3N=N(→O)CH3
Número CAS:
Peso molecular:
74.08
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352124
MDL number:
Assay:
≥98%
Form:
liquid
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)
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Quality Segment

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

General description

Azoximetano (OMA) é um potente produto químico laboratorial usado para estudar o início, a progressão e a prevenção do câncer, particularmente no cólon. Ele atua como carcinógeno, desencadeando a formação de tumores, e como agente de mutação genética, causando alterações específicas no DNA.

Application

O azoximetano (AOM), um agente de mutação gênica, pode ser usado com sulfato de sódico de dextrana (DSS) para criar modelos de câncer em animais de laboratório que podem ser usados para estudar os mecanismos de progressão e quimioprevenção do câncer.

Biochem/physiol Actions

Carcinógeno que induz adutos de O6-metilguanina no DNA levando a transições G→A. Induz tumorigênese no cólon de animais de laboratório e é usado para estudar o mecanismo de progressão do câncer e quimioprevenção.

Features and Benefits

Versátil e adaptável a uma ampla variedade de aplicações laboratoriais e de pesquisa.

Other Notes

Para mais informações sobre nossa linha de Bioquímicos, preencha este formulário.
É essencial determinar a dose correta de azoximetano para o design experimental para evitar a morte prematura dos animais de laboratório.

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Este Item
118502344906409081
Azoximetano 13.4 M, ≥98%

Sigma-Aldrich

A5486

Azoximetano

assay

≥98%

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

form

liquid

form

liquid

form

liquid

form

viscous liquid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

-

color

colorless

color

-

color

-

color

-


signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Classe de armazenamento

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C



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Questions

1–10 of 11 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 answer
    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      Helpful?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 answer
    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

      Helpful?

  5. Is Axozymethane volatile?

    1 answer
    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

      Helpful?

  6. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    1 answer
    1. Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

      Helpful?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 answer
    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  10. How does azoxymethane act to cause cancers?

    1 answer
    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      Helpful?

1–10 of 11 Questions  

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