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113R-2

Sigma-Aldrich

CD13 (EP117) Rabbit Monoclonal Primary Antibody

Sinônimo(s):

Aminopeptidase-N

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About This Item

Código UNSPSC:
12352203

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP117, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

forma

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (113R-24)
vial of 0.1 mL concentrate Research Use Only (113R-24-RUO)
vial of 0.5 mL concentrate (113R-25)
vial of 1.0 mL concentrate (113R-26)
vial of 1.0 mL concentrate Research Use Only (113R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (113R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (113R-27)
vial of 7.0 mL pre-dilute ready-to-use (113R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (113R-28-RUO)

fabricante/nome comercial

Cell Marque

concentração

0.1-5 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotipo

IgG

controle

liver

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

cytoplasmic, membranous

Informações sobre genes

human ... ANPEP(290)

Descrição geral

CD13 (aminopeptidase-N) is a transmembrane protease present in many tissues and cell types (e.g., endothelial and epithelial cells, fibroblasts, and leukocytes). CD13 is expressed in various solid and hematological malignancies in humans and is useful in identifying acute myeloid leukemia when used in a panel including antibodies against CD13(+), CD34(+), CD117(+), CD16(-), and CD33(+). This protein is also expressed in myeloid sarcoma and anti-CD13 is useful in its identification using a panel.

In addition, it has been reported that CD13 is expressed in both normal and neoplastic liver tissue, where it exhibits a canalicular distribution pattern similar to that seen for polyclonal CEA and CD10. Thus, anti-CD13 can be useful as an additional marker in differentiating between HCC and non-hepatocellular neoplasms.

Qualidade

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Ligação

CD13 Positive Control Slides, Product No. 113S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

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Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
Pileri SA, et al.
Leukemia, 21, 340-350 (2007)
Acute promyelocytic leukemia: four distinct patterns by flow cytometry immunophenotyping.
Gorczyca, W.
Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 1, 8-17 (2012)
Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma.
Rocken C, et al.
Journal of Clinical Pathology, 58, 1069-1075 (2005)
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Piedfer M, et al.
Faseb Journal, 25, 2831-2842 (2011)
Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.
Bauvois B, et al.
Medicinal Research Reviews, 26, 88-130 (2006)

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