RDD039

Imidazol

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri^™

• Sinônimo(s): 1,3-Diaza-2,4-ciclopentadieno, Glioxalina
• Fórmula empírica (Notação de Hill): C₃H₄N₂
• Número CAS: 288-32-4
• Peso molecular: 68.08
• Beilstein: 103853
• Número MDL: MFCD00005183
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• grau: Molecular Biology; for molecular biology
• Nível de qualidade: 100
• pressão de vapor: <1 mmHg ( 20 °C)
• linha de produto: Redi-Dri^™
• Ensaio: ≥99% (titration)
• Formulário: crystalline powder
• qualidade: free-flowing
• pH: 6.2-7.8 (25 °C)
• pKa (25 °C): 6.95
• p.e.: 256 °C (lit.)
• pf: 88-91 °C (lit.)
• aplicação(ões): diagnostic assay manufacturing
• atividade externa: DNase, RNase and protease, none detected
• cadeia de caracteres SMILES: c1c[nH]cn1
• InChI: 1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
• chave InChI: RAXXELZNTBOGNW-UHFFFAOYSA-N

Descrição

Descrição geral

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.[1]

Aplicação

Excelente para tampões na faixa de pH de 6,2-7,8

Imidazole has been used

• in the lysis, wash, and elution buffer for the purification of histidine tagged proteins[2]
• in gradient for the purification of histidine tagged proteins using nickel affinity chromatography[3]
• as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells[4]

Ações bioquímicas/fisiológicas

Imidazole derivatives have antibacterial, antifungal and anticancer functionality.[1] It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy.[5] It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).[6]

Características e benefícios

• Qualified for molecular biology applications, DNase, Rnase, and protease free
• Redi-Dri^™ packaging controls moisture, eliminating clumps
• Crystalline powder remains free-flowing and much easier to use
• Safer to handle and weigh out for routine use in lab
• Less waste, loss of drying, while maintaining high quality

Outras notas

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Informações legais

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Informações de segurança

• Pictogramas: GHS08,GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H314,H360D
• Declarações de precaução: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 293.0 °F - closed cup
• Ponto de fulgor (°C): 145 °C - closed cup