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Merck

O0877

Oxolinic acid

quinolone antibiotic

Sinônimo(s):

5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

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5 G

R$ 1.270,00

25 G

R$ 4.964,00

R$ 1.270,00

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Sobre este item

Fórmula empírica (Notação de Hill):
C13H11NO5
Número CAS:
14698-29-4
Peso molecular:
261.23
UNSPSC Code:
51282935
NACRES:
NA.85
PubChem Substance ID:
24278604
EC Number:
238-750-8
Beilstein/REAXYS Number:
620635
MDL number:
MFCD00056775

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Quality Level

200

antibiotic activity spectrum

Gram-negative bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12

InChI

1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)

InChI key

KYGZCKSPAKDVKC-UHFFFAOYSA-N

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Este Item
67126O0240000C8645
Oxolinic acid quinolone antibiotic

Sigma-Aldrich

O0877

Oxolinic acid

Oxolinic acid analytical standard

Supelco

67126

Oxolinic acid

Oxolinic acid European Pharmacopoeia (EP) Reference Standard

O0240000

Oxolinic acid

Cinoxacin

Sigma-Aldrich

C8645

Cinoxacin

antibiotic activity spectrum

Gram-negative bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-negative bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

-

mode of action

-

mode of action

DNA synthesis | interferes, enzyme | inhibits

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

200

solubility

0.5 M NaOH: soluble 50 mg/mL

solubility

-

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

General description

Chemical structure: quinolone

Application

Oxolinic acid is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia coli and Salmonella enterica. Oxolinic acid is added to culture medium for the isolation of Gardnerella vaginalis[1].

Biochem/physiol Actions

Oxolinic acid is a quinolone antibiotic. It is a DNA-gyrase (topoisomerase II) inhibitor used for studies on DNA winding and coiling and acts as a dopamine reuptake inhibitor for studies on dopaminergic neurotransmission processes.

Other Notes

5g,25g
Keep container tightly closed in a dry and well-ventilated place.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe de armazenamento

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000519071
0000519070
0000519070
0000519071
0000489214

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J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
Alketa Tarushi et al.
Journal of inorganic biochemistry, 103(6), 898-905 (2009-04-28)
The neutral mononuclear zinc complexes with the quinolone antibacterial drug oxolinic acid in the absence or presence of a nitrogen donor heterocyclic ligand 2,2'-bipyridine or 1,10-phenanthroline have been synthesized and characterized. The experimental data suggest that oxolinic acid is on
Takashi Aoki et al.
Marine biotechnology (New York, N.Y.), 13(4), 629-638 (2010-04-16)
Shrimp aquaculture is one of the major foodproducing industries in the world. However, it is being impacted by several problems including diseases, antibiotic use, and environmental factors. The extent of the effects of these problems in the immune system of
Quoc Tuc Dinh et al.
Talanta, 85(3), 1238-1245 (2011-08-03)
This study presents the development of an automated on-line solid phase extraction (SPE)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of 23 antibiotics in environmental water samples. After optimisation of LC-MS/MS conditions, SPE parameters such as sorbent type, sample
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Product Information Sheet - O0877

Product Information Sheet

Número de item de comércio global

SKUGTIN
O0877-25G04061834212652
O0877-5G04061835507078

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