N1636

β-Dinucleotídeo de nicotinamida adenina

purified by column chromatography, ≥99%

• Sinônimo(s): β-DPN, β-NAD, Coenzima 1, Cozimase, DPN, NAD, Nadide, Nucleotídeo de difosfopiridina
• Fórmula empírica (Notação de Hill): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
• Número CAS: 53-84-9
• Peso molecular: 663.43 (anhydrous basis)
• Número CE: 200-184-4
• Número MDL: MFCD00036253
• Código UNSPSC: 41106305
• eCl@ss: 39200202
• ID de substância PubChem: 24897510
• NACRES: NA.55

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥99%
• Formulário: crystalline powder
• cor: white
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
• chave InChI: BAWFJGJZGIEFAR-NNYOXOHSSA-N

Descrição

Descrição geral

β-Nicotinamide adenine dinucleotide (NAD) is an electron carrier[1] and a cofactor. It is ubiquitously found in the living system. NAD⁺ contains an adenylic acid and a nicotinamide-5′-ribonucleotide group linked together by a pyrophosphate moiety. In NAD⁺ complexes, the enzyme-cofactor interactions are highly conserved.[2]

Aplicação

β-Nicotinamide adenine dinucleotide hydrate has been used:

• to measure adenosine triphosphate (ATP) synthesis rates (kinetics measurements)[3]
• in the reaction buffer for pyruvate kinase (PK) activity assay[4]
• as a component of master mix for a high throughput screening[5]

Ações bioquímicas/fisiológicas

β-Nicotinamide adenine dinucleotide (NAD) cycles between the oxidized (NAD⁺⁾ and reduced (NADH) forms to maintain a redox balance necessary for continued cell growth.[6] It significantly participates in enzyme-catalyzed oxido-reduction processes[2] and many genetic processes. It is also involved in microbial catabolism.[6]

Aceptor de elétrons

Embalagem

Embalado com base no peso sólido.

Outras notas

Crystalline NAD contains less than 0.1% (w/w) residual organic solvent, is less hygroscopic and electrostatic, and is more stable at ambient temperatures than amorphous NAD.

Esta é a forma comum da NAD.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)