MTOX1302

Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells

canine kidney (cocker spaniel)

• Código UNSPSC: 41106514
• NACRES: NA.81

Propriedades

• product name: Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells,
• fonte biológica: canine kidney (cocker spaniel)
• forma: liquid
• Condições de expedição: dry ice
• temperatura de armazenamento: −196°C
• Informações sobre genes: human ... ABCG2(9429)

Descrição

Descrição geral

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP and Human OATP2B1 has been transfected into the MDCKII cell line. Validation studies have shown BCRP dependent efflux of estrone-3 sulfate (requires OATP2B1) and teriflunomide (does not require OATP2B1).

Características e benefícios

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.

Qualidade

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.

Informações legais

ADME/Tox Cell Lines License and HepaRG Limited Use License

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable