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I4386

Sigma-Aldrich

Iodoacetic acid

≥98.0% (T)

Sinônimo(s):

2-Iodoacetic acid

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About This Item

Fórmula linear:
ICH2CO2H
Número CAS:
64-69-7
Peso molecular:
185.95
Beilstein:
1739079
Número CE:
200-590-1
Número MDL:
MFCD00002685
Código UNSPSC:
12352106
ID de substância PubChem:
24896056
NACRES:
NA.77

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥98.0% (T)

forma

powder or flakes

cor

white to yellow

pf

77-79 °C (lit.)

solubilidade

H2O: soluble, clear to hazy

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC(=O)CI

InChI

1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)

chave InChI

JDNTWHVOXJZDSN-UHFFFAOYSA-N

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Aplicação

Iodoacetic acid has been used as an alkylating agent for antibody AR37, serum proteins and strawberry proteome samples extracted from different stages of ripened fruit.
Reagent for the modification of cysteine residues in proteins.

Ações bioquímicas/fisiológicas

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Pictogramas

Skull and crossbonesCorrosion
GHS06,GHS05

Palavra indicadora

Danger

Frases de perigo

H301,H314

Classificações de perigo

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
BCCM4203
BCCM4536
BCCH8786
BCCJ1462
BCCG9968

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Sigma-Aldrich

B56307

Bromoacetic acid

3-Iodopropionic acid 95%

Sigma-Aldrich

I10457

3-Iodopropionic acid

Database-independent Protein Sequencing (DiPS) Enables Full-length de Novo Protein and Antibody Sequence Determination
Savidor A, et al.
Molecular and Cellular Proteomics, 16(6), 1151-1161 (2017)
Drinking water disinfection byproduct iodoacetic acid induces tumorigenic transformation of NIH3T3 cells
Wei X, et al.
Environmental Science & Technology, 47(11), 5913-5920 (2013)
Carboxymethylation of cysteine using iodoacetamide/iodoacetic acid
The Protein Protocols Handbook, 455-456 (2002)
Development of candidate biomarkers for pancreatic ductal adenocarcinoma using multiple reaction monitoring
Yu J, et al.
Biotechnology and Bioprocess Engineering: BBE, 18(5), 1038-1047 (2013)
Antitumor activities of iodoacetate and dimethylsulphoxide against solid Ehrlich carcinoma growth in mice
Fahim FA, et al.
Biological Research, 36(2), 253-262 (2003)
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