61767
Lectin from Triticum vulgaris
lyophilized, ≥55% (GE), powder
Sinônimo(s):
WGA, Wheat germ agglutinin
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5 MG
R$ 983,00
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5 MG
R$ 983,00
About This Item
R$ 983,00
Check Cart for Availability
Produtos recomendados
fonte biológica
Triticum vulgaris
Formulário
powder
qualidade
lyophilized
concentração
≥55% (GE)
técnica(s)
agglutination assay: suitable using fresh human erythrocytes
temperatura de armazenamento
2-8°C
Categorias relacionadas
Descrição geral
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.[1]
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.[2]
Aplicação
Lectin from Triticum vulgaris has been used in bone resorption assays.[3]
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.[4]
Ações bioquímicas/fisiológicas
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.[1]
Outras notas
Molecular characteristics and specificity for sugar binding[2]
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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