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282820

Sigma-Aldrich

Protoporphyrin IX zinc(II)

guanylate cyclase inhibitor

Sinônimo(s):

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, 8,13-Divinyl-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid zinc derivative, Protoporphyrin IX zinc(II) complex

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About This Item

Fórmula empírica (Notação de Hill):
C34H32N4O4Zn
Número CAS:
15442-64-5
Peso molecular:
626.03
Número CE:
239-455-7
Número MDL:
MFCD00011612
Código UNSPSC:
12171500
ID de substância PubChem:
24857074
NACRES:
NA.47

Nível de qualidade

100

Ensaio

≥92% (HPLC)

forma

powder

cor

red to very dark red

λmax

426 nm

ε (coeficiente de extinção)

≥10000 at 585-591 nm in pyridine
≥12000 at 548-554 nm in pyridine
≥135000 at 423-429 nm in pyridine

aplicação(ões)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Zn]n34)c(C=C)c5C

InChI

1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

chave InChI

FUTVBRXUIKZACV-RGGAHWMASA-L

Categorias relacionadas

Descrição geral

Protoporphyrin IX zinc(II) (ZnPP) is an anti-oxidant enzyme heme oxygenase-1.

Aplicação

Cellular melanin content in normal human melanocytes treated with ZnPP has been studied. 1 It was used as a standard in a study where the excess formation of ZnPP in iron deficient erythropoiesis was determined by haematofluorometer.
Inhibits soluble guanylate cyclase.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
MKCQ4038
MKCL3047
MKCH9486
MKBV8659V
MKBR4657V

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Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women
Mwangi M, et al.
BMC Medicine, 12(1), 1-1 (2014)
Ying Feng et al.
Biochemical and biophysical research communications, 456(2), 549-554 (2014-09-30)
Hyperoxic acute lung injury (HALI) is a clinical syndrome as a result of prolonged supplement of high concentrations of oxygen. Previous studies have shown hyperbaric oxygen preconditioning (HBO-PC) had a protective effect on oxidative injury. In the present study, we
Sha Huang et al.
Translational lung cancer research, 9(6), 2337-2355 (2021-01-26)
The therapeutic efficacy of cisplatin-based chemotherapy for non-small cell lung cancer (NSCLC) is limited by drug resistance. In NSCLC, hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) counteracts oxidative stress to promote chemoresistance. Metformin-mediated downregulation of Nrf2 plays a
Marcio Jose Ferreira et al.
Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell
Shiliu Tian et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 5-13 (2014-04-18)
This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic endothelial cells (HAECs) and a type 2 diabetic animal model. The effect of RPL on vasodilatory function in fat-fed
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