691550-M

Zinc (II) Protoporphyrin IX

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin.

• Sinônimo(s): Zinc (II) Protoporphyrin IX, ZnPP-9
• Fórmula empírica (Notação de Hill): C₃₄H₃₂N₄O₄Zn
• Número CAS: 15442-64-5
• Peso molecular: 626.03
• Número MDL: MFCD00011612
• Código UNSPSC: 12171500
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (TLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: dark red
• solubilidade: DMF: soluble; pyridine: soluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Zn+2].[n-]1c2cc3nc(cc4[n-]c(cc5nc(cc1c(c2CCC(=O)O)C)c(c5C=C)C)c(c4C=C)C)c(c3CCC(=O)O)C
• InChI: 1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13?,26-13-,27-14?,28-15-,29-14-,30-15?,31-16-,32-16?;
• chave InChI: FUTVBRXUIKZACV-RGUWPKJZSA-L

Descrição

Descrição geral

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 0.8 µM, 4.0 µM, and 5.0 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron deficient erythropoiesis. Does not cross the blood-brain barrier.

Ações bioquímicas/fisiológicas

Primary Target
heme oxygenase

Target IC₅₀: 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively

Advertência

Toxicity: Standard Handling (A)

Outras notas

Wolff, D.J., et al. 1996. Arch. Biochem. Biophys.333, 27.
Bing, O., et al. 1995. NeuroReport 6, 1369.
Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
Kadoya, C., et al. 1995. Stroke 26, 1035.
Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
Zhuo, M., et al. 1993. Science 260, 1946.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable