610225

Tigecycline

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria.

• Sinônimo(s): Tigecycline, 9- t-Butylglycylamido-minocycline, 9-t-Butylglycylamido-minocycline
• Fórmula empírica (Notação de Hill): C₂₉H₃₉N₅O₈
• Número CAS: 220620-09-7
• Peso molecular: 585.65
• Número MDL: MFCD00935753
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (HPLC)
• forma: powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: orange
• solubilidade: DMSO: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(C1=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C[C@]1([H])C3)C4=C3C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C4O
• InChI: 1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,41-42H,8-9,11,30H2,1-7H3,(H,32,35)/b27-20-/t12-,14-,21-,29-/m0/s1
• chave InChI: ZXGBRIBPJBHLMO-SBMFAFPZSA-N

Descrição

Descrição geral

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD₅₀ ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Skrtic, M., et al. 2011. Cancer Cell20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother.50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis.43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother.56, 611.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS08,GHS05,GHS07,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H317,H318,H360FD,H410
• Declarações de precaução: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable