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PZ0021

Sigma-Aldrich

Tigecycline hydrate

≥98% (HPLC)

Sinônimo(s):

9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tigecyclin, Tygacil

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About This Item

Fórmula empírica (Notação de Hill):
C29H39N5O8 · xH2O
Número CAS:
1229002-07-6
Peso molecular:
585.65 (anhydrous basis)
Código UNSPSC:
12352200
ID de substância PubChem:
329823688
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

≥98% (HPLC)

Formulário

powder

atividade óptica

[α]/D -175 to -205°, c = 0.15 in methanol

cor

off-white to yellow-brown

solubilidade

DMSO: ≥3 mg/mL (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

InChI

1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1

chave InChI

PMPLAEFBZIFHAR-KXLOKULZSA-N

Descrição geral

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.[1]

Aplicação

TIGECYCLINE HYDRATE has been used:
  • for antibiotic susceptibility testing[2]
  • to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines[3]
  • to evaluate its effects on the binding of fluoroquinolones to human serum albumin[4]
  • as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor[5]

Ações bioquímicas/fisiológicas

Tigecycline is a broad spectrum glycylcycline antibiotic.
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Outras notas

air sensitive

Palavra indicadora

Danger

Frases de perigo

H317,H318,H360FD,H410

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000321754
0000269500
0000269497
110M4712V

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Hubert Ziółkowski et al.
Poultry science, 99(10), 4750-4757 (2020-09-30)
Tetracyclines continue to be important antimicrobials in veterinary medicine. However, the pharmacokinetics (PK) of tigecycline (TIG) and minocycline (MIN) in broiler chickens has not been investigated to date, and the PK of chlortetracycline (CTC) and tetracycline (TET) remains insufficiently researched
The Effect of Tigecycline on the Binding of Fluoroquinolones to Human Serum Albumin
Jelic RM, et al.
Serbian Journal of Experimental and Clinical Research, 19(1), 17-25 (2018)
A Jasiecka-Mikołajczyk et al.
Journal of veterinary pharmacology and therapeutics, 41(1), e22-e29 (2017-08-24)
The aim of this research had been to determine the pharmacokinetics of tigecycline (TIG) in turkey after intravenous (i.v.), intramuscular (i.m.), subcutaneous (s.c.), and oral (p.o.) administration at a dose of 10 mg/kg. TIG concentrations in plasma were determined using high-performance
Tigecycline targets nonsmall cell lung cancer through inhibition of mitochondrial function
Jia X, et al.
Fundamental & Clinical Pharmacology, 30(4), 297-306 (2016)
In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections
Bradford PA, et al.
Clinical Infectious Diseases, 41 (2005)
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