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Sigma-Aldrich

TAPI-0

≥96% (HPLC), solid, collagenase, gelatinase, and TACE inhibitor, Calbiochem®

Sinônimo(s):

TAPI-0, N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0

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About This Item

Fórmula empírica (Notação de Hill):
C24H32N4O5
Número CAS:
143457-40-3
Peso molecular:
456.53
Código UNSPSC:
12352200
NACRES:
NA.77

product name

TAPI-0, TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).

Nível de qualidade

100

Ensaio

≥96% (HPLC)

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
desiccated (hygroscopic)
protect from light

cor

white

solubilidade

50% acetic acid: 1 mg/mL
DMSO: 5 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

−20°C

InChI

1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1

chave InChI

CRCPLBFLOSEABN-VBSNWNEZSA-N

Descrição geral

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50 = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
TNF-α converting enzyme/ADAM17
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

Informações legais

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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