D048

MPP⁺ iodide

≥98% (HPLC), powder

• Sinônimo(s): 1-Methyl-4-phenylpyridinium iodide
• Fórmula empírica (Notação de Hill): C₁₂H₁₂IN
• Número CAS: 36913-39-0
• Peso molecular: 297.13
• Número MDL: MFCD00055096
• Código UNSPSC: 12352200
• ID de substância PubChem: 24893235
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 10 mg/mL, clear
• cadeia de caracteres SMILES: [I-].C[n+]1ccc(cc1)-c2ccccc2
• InChI: 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
• chave InChI: RFDFRDXIIKROAI-UHFFFAOYSA-M

Descrição

Descrição geral

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.[1]induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes.[2] It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells.[3] MPP+ modulates the distribution of dopamine.[4] It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.[5]

Aplicação

MPP+ iodide has been used:

• to induce oxidative stress in zebrafish embryos[6]
• for the inhibition of glutamate uptake in mitochondria of astrocytes[7]
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells[8]

Ações bioquímicas/fisiológicas

Active metabolite of dopaminergic neurotoxin MPTP

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Atenção

Photosensitive.

Nota de preparo

Solutions should be freshly prepared.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301 + H311 + H331,H315,H319,H335
• Declarações de precaução: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges