573108-M

STAT5 Inhibitor

The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.

• Sinônimo(s): STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
• Fórmula empírica (Notação de Hill): C₁₆H₁₁N₃O₃
• Número CAS: 285986-31-4
• Peso molecular: 293.28
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 25 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC₅₀ = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

Advertência

Toxicity: Standard Handling (A)

Outras notas

Muller, J., et al. 2008. ChemBioChem9, 723.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable