475895

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

• Sinônimo(s): Monensin, Sodium Salt, High Purity
• Fórmula empírica (Notação de Hill): C₃₆H₆₁O₁₁ · Na
• Número CAS: 22373-78-0
• Peso molecular: 692.85
• Número MDL: MFCD00077826
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (by Assay)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: off-white to beige
• solubilidade: chloroform: soluble; ethanol: soluble; methanol: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
• chave InChI: XOIQMTLWECTKJL-FBZUZRIGSA-M

Descrição

Descrição geral

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Functions as a Na+ ionophore

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Highly Toxic (H)

Reconstituição

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H300,H319,H373,H411
• Declarações de precaução: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Classificações de perigo: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Órgãos-alvo: Heart,muscle
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable