344931-M

Furin Inhibitor II

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinônimo(s): Furin Inhibitor II, Hexa-D-arginine, H-(D)RRRRRR-NH₂
• Fórmula empírica (Notação de Hill): C₃₆H₇₅N₂₅O₆
• Peso molecular: 954.14
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: water: 1 mg/mL; DMSO: soluble
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.

A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.

Ações bioquímicas/fisiológicas

Primary Target
furin

Target K_i: 106 nM against Furin

Advertência

Toxicity: Standard Handling (A)

Sequência

H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂

forma física

Supplied as a trifluoroacetate salt.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable