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SCP0148

Sigma-Aldrich

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

Sinônimo(s):

Hexa-D-arginine amide

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About This Item

Fórmula empírica (Notação de Hill):
C36H75N25O6
Peso molecular:
954.14
Código UNSPSC:
12352202
NACRES:
NA.32

R$ 2.224,00

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Nome do produto

Furin Inhibitor II,

Ensaio

≥95% (HPLC)

Formulário

lyophilized

composição

Peptide Content, ≥48%

condição de armazenamento

protect from light

técnica(s)

protein extraction: suitable

temperatura de armazenamento

−20°C

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

Descrição geral

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family.[1] It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.[1]

Aplicação

Furin Inhibitor II has been used as a furin inhibitor:
  • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).[2]
  • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.[3]
  • in furin cleavage assay.[4]

Ações bioquímicas/fisiológicas

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).[5]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
E278093
E257140
E1094
MI1170

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Poly-L-arginine hydrochloride mol wt 15,000-70,000

Sigma-Aldrich

P7762

Poly-L-arginine hydrochloride

Polyarginines are potent furin inhibitors
Cameron A, et al.
The Journal of Biological Chemistry, 275(47), 36741-36749 (2000)
Emily J Schepers et al.
The Journal of surgical research, 282, 118-128 (2022-10-23)
Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin is a proprotein convertase that is ubiquitously expressed and shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers
Jingwen Yin et al.
Cells, 9(1) (2020-01-16)
Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1 (TGF-β1) plays an important role in
A Cameron et al.
The Journal of biological chemistry, 275(47), 36741-36749 (2000-08-26)
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
Dubois C M, et al.
The American Journal of Pathology, 158(1), 305-316 (2001)
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Questions

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  1. How can product SCP0148, Furin Inhibitor II, be dissolved?

    1 answer

    1. Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.

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  2. What is the Department of Transportation shipping information for this product?

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    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. How can Product SCP0148, Furin Inhibitor II be dissolved?

    1 answer

    1. Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.

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